HPC Cloud Updates WE 23 Nov 2025

Updates to AWS, Azure & GCP in the last week relevant for HPC practitioners. SC25 just wrapped up, what did the cloud providers give us? AWS has a lot, not too surprising given re:Invent is just around the corner too. Tasty Blackwell Chips Ahoy from AWS and Azure

HPC Cloud Updates WE 23 Nov 2025

AWS

Using PCS for drug discovery

How Daiichi Sankyo modernized drug discovery using AWS Parallel Computing Service | Amazon Web Services
This blog was co-authored by Takehiro Nakajima and Mark Azadpour from AWS and Rintaro Yamada, Rei Kajitani and Ryo Kunimoto from Daiichi Sankyo In recent years, the informatics field of drug discovery has seen a rapid increase in workloads requiring large-scale parallel computing, such as genome analysis, structure prediction, and drug design. Daiichi Sankyo has […]

PCS now also supports the Slurm REST API and is HIPAA eligible

AWS Parallel Computing Service now supports Slurm REST API - AWS
Discover more about what’s new at AWS with AWS Parallel Computing Service now supports Slurm REST API
AWS Parallel Computing Service is now HIPAA eligible - AWS
Discover more about what’s new at AWS with AWS Parallel Computing Service is now HIPAA eligible

Want to see how cost efficient your AWS HPC is?

Measuring Cloud Cost Efficiency with the New Cost efficiency metric by AWS | Amazon Web Services
As organizations continue to scale their cloud infrastructure, many organizations struggle to answer fundamental questions: How efficient are we being with our cloud spend? Which business units are most cost efficient? How do we demonstrate ROI on optimization efforts to leadership? Today, we’re excited to introduce Cost efficiency in Cost Optimization Hub—a comprehensive, automatically generated measure of cloud spend efficiency that helps you track optimization progress over time and drive meaningful cost savings across your organization.

Nvidia B300 (Blackwell) GPUs now available

Amazon EC2 P6-B300 instances with NVIDIA Blackwell Ultra GPUs are now available - AWS
Discover more about what’s new at AWS with Amazon EC2 P6-B300 instances with NVIDIA Blackwell Ultra GPUs are now available

There was talk of a new hpc8a coming but its not in the release notes yet though it seems it is promised for 2026

Meet the Advanced Computing team of AWS at SC25 in St. Louis | Amazon Web Services
We want to empower every scientist and engineer to solve hard problems by giving them access to the compute and analytical tools they need, when they need them. Cloud HPC can be a real human progress catalyst. If you run large scale simulations, tune complex models, or support researchers who consistently need more compute, the […]

EC2 Image Building now supports automatic versioning for recipes and lets you create workflows to distribute them

EC2 Image Builder now supports auto-versioning and enhances Infrastructure as Code experience - AWS
Discover more about what’s new at AWS with EC2 Image Builder now supports auto-versioning and enhances Infrastructure as Code experience
Announcing flexible AMI distribution capabilities for EC2 Image Builder - AWS
Discover more about what’s new at AWS with Announcing flexible AMI distribution capabilities for EC2 Image Builder

Want to make your CISO happy? Turn on the new VPC Encryption Controls

AWS introduces new VPC Encryption Controls and further raises the bar on data encryption - AWS
Discover more about what’s new at AWS with AWS introduces new VPC Encryption Controls and further raises the bar on data encryption

and Fleet lets you add encryption as an instance selection parameter too

Amazon EC2 Fleet adds new encryption attribute for instance type selection - AWS
Discover more about what’s new at AWS with Amazon EC2 Fleet adds new encryption attribute for instance type selection

and you can now launch new instances synchronously

EC2 Auto Scaling now offers a synchronous API to launch instances inside an Auto Scaling group - AWS
Discover more about what’s new at AWS with EC2 Auto Scaling now offers a synchronous API to launch instances inside an Auto Scaling group

Lustre in AWS flavour gets a performance boost for listing directories

Amazon FSx for Lustre improves directory listing performance by up to 5x - AWS
Discover more about what’s new at AWS with Amazon FSx for Lustre improves directory listing performance by up to 5x

New Regional Instances: r8i and its flex cousin in Sydney, Canada and California, c7i in Melbourne, m7i in Zurich and m8i and flex in Mumbai.


Azure

Azure has some tasty new Blackwell chips for us too

Azure ND GB300 v6 now Generally Available - Hyper-optimized for Generative and Agentic AI workloads | Microsoft Community Hub
We are pleased to announce the General Availability (GA) of ND GB300 v6 virtual machines, delivering the next leap in AI infrastructure. On 10/09, we shared…

Cycle Cloud 8.8 and Slurm Workspace 1.2 released

Azure CycleCloud 8.8 and CCWS 1.2 at SC25 and Ignite | Microsoft Community Hub
Azure CycleCloud 8.8: Advancing HPC & AI Workloads with Smarter Health Checks Azure CycleCloud continues to evolve as the backbone for orchestrating…

Public preview of Azure Managed Lustre, I guess Microsoft is finally deciding we need more than Azure Files for HPC

Announcing the Public Preview of AMLFS 20: Azure Managed Lustre New SKU for Massive AI&HPC Workloads | Microsoft Community Hub
Sachin Sheth - Principal PDM Manager Brian Barbisch - Principal Group Software Engineering Manager Matt White - Principal Group Software Engineering…

Google Cloud

New region in Türkiye coming soon

New Google Cloud region coming to Türkiye | Google Cloud Blog
When open, the new Google Cloud region in Türkiye will help meet growing demand for cloud services and AI-driven innovation in the country and EMEA.

Roundup of recent Google announcements that were showcased at SC25

Accelerating innovation and discovery at SC25 | Google Cloud Blog
At SC25, come learn how Google Cloud is democratizing HPC for startups, academics, labs, and enterprise teams alike.